Calculator
Reta dose calculator
Enter a starting weekly dose, target dose, step size and interval. The calculator returns a step-by-step escalation schedule and the total number of weeks to reach the target. Defaults follow the reta Phase 3 ladder (1 → 12 mg in 4-week steps). For mechanism context, read how reta works.
For in-vitro laboratory research planning. Not medical advice.
How reta trial titration is structured
Phase 3 reta trials use a slow weekly ladder: 1 mg → 2 mg → 4 mg → 8 mg → 12 mg, with 4 weeks at each step. That's a 16-week escalation phase before the maintenance window at the top dose. Slower titration is used at trial sites that report higher GI events; faster is used at sites where tolerability is good.
The ladder is not linear because GI side-effect risk scales with the percentage jump in dose, not the absolute mg. Going from 1 to 2 mg is a 100% jump, but tolerability is generally fine. Going from 8 to 12 mg is a 50% jump, but the absolute mg increase is larger and the glucagon-component effects are more noticeable. The default settings here apply a uniform step size for simplicity; real trial schedules use varied steps.
Planned the ladder? Match it to a verified pen
Every Reta pen and vial in this schedule has a Janoshik COA in the library. Confirm the batch purity, then find research-use availability for that format on Remy Peptides.