TB-500 10mg Vial

Thymosin beta-4 (Tβ4) is a 43-amino-acid peptide found in most mammalian cells, where it acts as the main buffer for monomeric G-actin. It binds G-actin one-to-one and helps set how much actin is free to build filaments, which shapes how cells move and change shape.

TB-500 is the market name for something smaller. Analytical and doping-control chemistry identifies the compound sold under this label as a short acetylated synthetic fragment, Ac-LKKTETQ, taken from the actin-binding region of Tβ4. That matters when you read the literature: most published work, and every human trial on record, used the full-length protein. Findings from Tβ4 papers describe a related molecule, not this vial.

Our TB-500 research overview walks through the mechanism and evidence in more depth. This listing is a 10mg lyophilized research vial, labelled ProPeptide, for in-vitro laboratory work only.

Three things decide whether a research vial is worth ordering: what is in it, how it was handled, and how fast it reaches the bench.

Identity and purity on record

TB-500 is supplied to a >99% HPLC line standard, with mass spectrometry as the identity method. Published independent batch reports sit in our lab results library; check there for the batches currently documented.

Kept cold from store to door

The freeze-dried peptide ships in cold-chain packaging that holds 2–8°C. In UAE heat, the last stretch of delivery is the usual stability risk, so the vial is not left at room temperature on the way.

Delivered across the seven emirates

Dubai orders placed before 4 PM go out the same day, and most arrive within 4 hours. For the other emirates, order before 12 PM (noon) for next-day arrival; later orders arrive within two days. Full terms are on the delivery page.

Most of the evidence comes from cell culture and animal models, much of it using full-length Tβ4 rather than the fragment. Short actin-binding fragments have shown activity in preclinical models, but results for one molecule should not be assumed for the other.

Actin and cell movement

By controlling the pool of free G-actin, Tβ4 influences lamellipodial protrusion and the migration of fibroblasts and keratinocytes. These are the cell behaviours that close a wound surface, which is why actin work anchors this research area.

New vessel growth

In-vitro and rodent studies report that Tβ4 encourages endothelial cells to migrate and form tube-like structures, with collateral vessel growth in ischaemic tissue. This is one of the more often replicated signals in the field.

Heart, eye and skin injury models

A 2004 mouse study after induced myocardial infarction linked Tβ4 to cardiomyocyte survival through integrin-linked kinase signalling. Rabbit and rodent corneal models show faster re-epithelialisation, and rat and diabetic-mouse skin wounds closed faster in published work, including one arm testing an actin-binding-domain peptide.

The AcSDKP side-story

The N-terminal tetrapeptide of Tβ4, AcSDKP, is studied separately as an anti-fibrotic and haematopoietic regulator. Claims that bundle this activity under the TB-500 name are mixing two distinct pieces of biology.

The two are often mentioned together, yet they work on different biology. For the full side-by-side, read BPC-157 vs TB-500. Remy Research also lists a BPC-157 + TB-500 blend vial and a TB-500 20mg pen.